Optimized SEEG-guided radiofrequency thermocoagulation in the treatment of pediatric hypothalamic hamartomas

PurposeThis study investigated the role of one-stage stereo-array radiofrequency thermocoagulation based on stereotactic electroencephalography in treatment pediatric hypothalamic hamartomas.MethodsWe analyzed clinical data 28 patients with hamartoma. A high-density focal electrode implantation strategy was adopted. Stereotactic guided bipolar coagulations were performed between two contiguous contacts same electrode, or adjacent different electrodes. Patients hamartoma divided into groups size (maximum diameter < 15 mm vs maximum ? mm). Numbers implanted electrodes and used for documented. Seizure outcome evaluated according to Engel’s classification.ResultsSurgical procedures well tolerated no repeated surgery performed. The median number significantly (p = 0.0009), as where applied 0.0006). Moreover, positively correlated volume (Spearman's rho 0.7074, p?0.0001 Spearman's 0.7435, p?0.0001, respectively). overall seizure-free rate 82.1 %, 92.9 % having favorable outcomes at least 12 months follow-up. not statistically significant 0.3138).ConclusionOne-stage using cross-bonded ablation range expansion is a safe effective surgical approach children